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KMID : 1134820090380081016
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Journal of the Korean Society of Food Science and Nutrition
2009 Volume.38 No. 8 p.1016 ~ p.1023
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Effect of Artemisia capillaris and Paecilomyces japonica on the Reduction of Hepatotoxicity and Lipid Metabolism Induced by Ethanol
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Han Eun-Kyung
Kim Young-Sup
Yoo Youn-Sook
Chung Cha-Kwon
Jung Eui-Jin
Lee Ji-Young
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Abstract
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The purpose of this study was to identify the inhibitory effect of hepatic toxicity and liver lipid metabolism after administration of Artemisia capillaris and Paecilomyces japonica. Along with the control, SD rats were divided into ethanol treated group with subgroups of 6% Artemisia capillaries (6A), 4% Artemisia capillaris＋2% Paecilomyces japonica (4A2P), 3% Artemisia capillaris＋3% Paecilomyces japonica (3A3P), 2% Artemisia capillaris＋4% Paecilomyces japonica (2A4P) and 6% Paecilomyces japonica (6P). In this study we also intended to verify the optimum ratio of Artemisia capillaris and Paecilomyces japonica which can reduce hepatotoxicity. Artemisia capillaris and Paecilomyces japonica reduced cholesterol and triglyceride levels which were increased by ethanol. Total-cholesterol level was decreased the most in the groups of 4A2P and 3A3P. On the other hand, activity of superoxide dismutase (SOD) was enhanced significantly (p＜0.05). Malondialdehyde (MDA) activity was decreased significantly (p＜0.05) in the subgroup of 6A and 4A2P. When the ratio of Artemisia capillaris and Paecilomyces japonica was 2:1, the improvement of the rat serum and liver lipid metabolism and the alleviation of hepatic damage by ethanol were the most effective in this study. Therefore, it can be considered that the symptoms of severe chemically induced hepatotoxicity could be reduced by Artemisia capillaris and Paecilomyces japonica administration.
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KEYWORD
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Artemisia capillaris, Paecilomyces japonica, ethanol, hepatotoxicity
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